NMN
Nicotinamide Mononucleotide
The direct precursor to NAD+ — the currency of cellular youth.
Full profile →- Origin
Naturally present in trace amounts in food; supplemented as crystalline powder
- Format
Capsule or sublingual
- Best time
Morning, on an empty stomach
What it is
Nicotinamide mononucleotide is a nucleotide that the body converts directly into NAD+, a coenzyme found in every living cell. NAD+ is involved in more than five hundred enzymatic reactions — energy metabolism, DNA repair, sirtuin activation.
How it works
NMN is converted into NAD+ via the salvage pathway. NAD+ is then consumed by sirtuins (involved in longevity signalling), PARPs (DNA repair) and the mitochondrial electron transport chain.
The protocol
250–500 mg daily, taken in the morning. Consistency over months matters more than dose.
Sourcing
Look for ≥99% purity, third-party COA, and stable packaging — NMN is moisture-sensitive. Beta-form only.
Honest caution
Generally well tolerated. Speak with a clinician if you have a history of cancer, are pregnant, or take medications that affect methylation.
What it supports
- Cellular energy — Replenishes NAD+ for mitochondrial output.
- Healthy aging signalling — Activates sirtuins involved in longevity pathways.
- DNA repair support — Fuels PARP enzymes that repair daily DNA damage.









