Longevity
The long arc of a well-lived body.
Longevity is not a single supplement. It's the accumulated quality of every system — mitochondria, immune, vascular, cognitive, gut.
NAD+ precursors, CoQ10, polyphenols, adaptogens, and a real diet do more, together, than any single 'longevity molecule' alone.
Ingredients that support this
Products for Longevity
EVIDENCE
The studies behind this
NAD+ precursors (NMN, NR) raise blood NAD+ in human RCTs. CoQ10 supports mitochondrial bioenergetics. Berberine improves the metabolic markers most predictive of healthspan.
What the studies say
NAD+ precursors (NMN, NR) are the most-studied longevity supplements of the past decade. Multiple human RCTs now confirm they raise blood NAD+ — the question of clinical benefit beyond that biomarker is active research.
Honest caveatRaising NAD+ in blood is well-replicated. Translating that biomarker into measurable healthspan/anti-ageing outcomes in humans is still being tested.
- 01RCT
Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term NMN supplementation: a randomised, double-blind, placebo-controlled trial
Katayoshi T, Uehata S, Nakashima N, Nakajo T, Kitajima N, Kageyama M, Tsuji-Naito K · Scientific Reports (Nature) · 2023
“Long-term oral NMN supplementation significantly increased blood NAD+ concentrations and was associated with improvements in arterial stiffness markers compared with placebo.”
Plain EnglishRandomised, placebo-controlled human trial: NMN raises blood NAD+ and improves arterial stiffness over the long-term protocol.
- 02RCT
Association between blood NAD levels and laboratory parameters at baseline and after NMN supplementation in middle-aged healthy individuals
Various · GeroScience (Springer) · 2025
“Post-hoc analysis confirmed dose-dependent increases in blood NAD+ with NMN and identified associations with several blood-chemistry parameters in middle-aged healthy adults.”
Plain EnglishConfirms dose-dependent NAD+ increase and links NAD+ levels to specific blood-chemistry markers.
All citations link to PubMed, PubMed Central or the original publisher. We do not reproduce full study text. References last verified by SACRAHAUS editorial.
What the studies say
CoQ10 (ubiquinone / ubiquinol) is a mitochondrial cofactor with the strongest clinical signal in heart-failure and statin-associated muscle symptoms. Cardiology reviews now consistently support adjunctive use.
Honest caveatEffects are clearest in deficiency or pathology (heart failure, statin myopathy, mitochondrial dysfunction). Benefit in healthy young adults is much smaller.
- 01META-ANALYSIS
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis
Various · Future Cardiology · 2024
“Ubiquinol supplementation was associated with improvements in left-ventricular ejection fraction and functional status in patients with chronic heart failure.”
Plain EnglishIn chronic heart failure, ubiquinol improves measurable cardiac function and exercise capacity.
- 02PEER-REVIEWED REVIEW
Coenzyme Q10 in Cardiovascular Medicine: Mechanisms, Clinical Evidence, and Future Integration in Heart Failure and Statin Myopathy
Various · PubMed-indexed review · 2025
“CoQ10 supplementation is supported by evidence in chronic heart failure and statin-associated muscle symptoms, with a strong mechanistic basis in mitochondrial bioenergetics.”
Plain EnglishModern review consolidates the heart-failure and statin-myopathy evidence and explains the mitochondrial mechanism.
All citations link to PubMed, PubMed Central or the original publisher. We do not reproduce full study text. References last verified by SACRAHAUS editorial.
What the studies say
Berberine is one of the few botanical compounds with metabolic effects approaching those of pharmacological agents in trial settings — particularly on fasting glucose, HbA1c and lipid profile. Multiple meta-analyses converge on a real glucose-lowering effect.
Honest caveatBerberine is not a substitute for prescribed diabetes medication and should not be combined with one without medical supervision. GI side effects are common at higher doses.
- 01META-ANALYSIS
Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis
Guo J, et al. · Frontiers in Pharmacology · 2022
“Berberine significantly reduced fasting blood glucose, postprandial glucose and HbA1c compared with control across pooled randomised trials in adults with type 2 diabetes.”
Plain EnglishBerberine meaningfully lowers fasting glucose, post-meal glucose and HbA1c versus placebo in T2D.
- 02META-ANALYSIS
Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of RCTs
Various · The Journal of Nutrition · 2024
“Pooled analysis showed significant improvements in fasting glucose, fasting insulin and HOMA-IR with berberine supplementation versus control.”
Plain EnglishBeyond glucose, berberine improves fasting insulin and insulin-resistance markers (HOMA-IR).
- 03META-ANALYSIS
The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis of RCTs
Various · Clinical Therapeutics · 2024
“An umbrella meta-analysis confirmed favourable effects of berberine on glycaemic control and inflammatory biomarkers across metabolic disorders.”
Plain EnglishUmbrella review (meta-analysis of meta-analyses) confirms the glucose and inflammation signal is consistent.
All citations link to PubMed, PubMed Central or the original publisher. We do not reproduce full study text. References last verified by SACRAHAUS editorial.
Questions
- Is there a single longevity supplement?
- No, despite the marketing. The longest-lived populations share lifestyle factors — diet, movement, social connection — that no capsule replaces.
PUT IT INTO PRACTICE
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