SACRAHAUS Mushroom Blend Elixir with Prebiotics & Vitamin C

Lion's Mane (Hericium erinaceus) is most associated with nerve growth factor (NGF) signalling and mild cognitive benefit. Human evidence is still smaller than the brand category implies, but a 2025 Frontiers in Nutrition systematic review consolidates the dataset.

Caveat: Effects are most clearly documented in mild cognitive impairment and short-term mood; a strong nootropic effect in healthy young adults is not yet established.

• SYSTEMATIC REVIEWFrontiers in Nutrition · 2025

  Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

  Various, College of Medicine team

  "Hericium erinaceus shows the most consistent benefit on cognitive function in older adults with mild cognitive impairment, with limited but encouraging data on mood and depressive symptoms."

  Most reliable cognitive evidence is in older adults with MCI; mood data is preliminary but positive; safety profile is good.

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• SYSTEMATIC REVIEWDebates em Psiquiatria · 2023

  Use of Hericium erinaceus as a potential therapeutic of mental disorders: a systematic review

  Various

  "Across included trials, Hericium erinaceus supplementation was associated with reductions in anxiety and depressive symptoms relative to control conditions."

  Early human signal for anxiety and depressive symptom reduction; needs larger replications.

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Reishi (Ganoderma lucidum) is best characterised for its β-glucan polysaccharides and triterpenes, with a long traditional use for fatigue, sleep and immune balance. Modern reviews summarise an extensive mechanistic literature with a smaller but growing human dataset.

Caveat: Most clinical evidence is in cancer-supportive care contexts (alongside chemotherapy); robust placebo-controlled trials in healthy adults remain limited.

• PEER-REVIEWED REVIEWJournal of Pharmaceutical Analysis · 2023

  Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

  Various

  "Across pre-clinical and clinical studies, Ganoderma lucidum demonstrates immunomodulatory, antioxidant and anti-fatigue activities, with a generally favourable safety profile at studied doses."

  Comprehensive modern review confirms immune-modulating, antioxidant and anti-fatigue activity with a good safety profile.

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• RCTFoods · 2023

  Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomised Controlled Trial

  Chen S-N, Nan F-H, et al.

  "Reishi-derived β-glucan supplementation modulated immune-cell markers in healthy volunteers compared with placebo over the trial period."

  Placebo-controlled trial in healthy adults shows measurable immune-cell modulation from reishi β-glucan.

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Vitamin C is one of the few supplements with a Cochrane-level review on its most-claimed use. The honest reading is: it does not prevent the common cold in the general population, but it modestly shortens duration and is more useful under physical stress.

Caveat: Daily prophylactic dosing in healthy adults gives small benefit. Therapeutic dosing started AT symptom onset shows little effect in most trials.

• META-ANALYSISCochrane Database of Systematic Reviews · 2013

  Vitamin C for preventing and treating the common cold

  Hemilä H, Chalker E

  "Regular vitamin C supplementation did not reduce cold incidence in the general population but consistently reduced cold duration and severity, with larger effects in people exposed to short periods of extreme physical stress."

  Cochrane: vitamin C doesn't prevent colds in healthy adults but shortens them; bigger effect in athletes and high-stress populations.

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• PEER-REVIEWED REVIEWTrends in Immunology / PMC · 2017

  Vitamin C, respiratory infections and the immune system

  Carr AC, Maggini S

  "Vitamin C contributes to immune defence by supporting various cellular functions of both the innate and adaptive immune systems."

  Vitamin C is required by multiple immune-cell functions; deficiency impairs both innate and adaptive immunity.

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Chaga (Inonotus obliquus) is exceptionally rich in melanin polymers, β-glucans and triterpenes. Mechanistic and pre-clinical data are extensive; controlled human-trial data is still developing.

Caveat: Most published evidence is mechanistic / pre-clinical. We do not make disease-treatment claims for chaga.

• PEER-REVIEWED REVIEWHeliyon · 2024

  A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms

  Camilleri E, Blundell R, et al.

  "Inonotus obliquus exhibits well-characterised antioxidant, immunomodulatory and metabolic activities, with a deep traditional-use record across northern boreal cultures."

  Modern peer-reviewed overview confirms antioxidant, immune-modulating and metabolic activity classes.

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• PEER-REVIEWED REVIEWPolymers · 2021

  Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

  Various

  "Chaga polysaccharides — particularly β-glucans — display notable immunomodulatory and antioxidant biological activities in pre-clinical and early clinical work."

  Detailed phytochemistry review of chaga's β-glucans and their biological activities.

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