Every ingredient,
answerable to evidence.

Ashwagandha

Withania somnifera

Ashwagandha (Withania somnifera) has the deepest human evidence base of any adaptogen we use. Multiple meta-analyses now show meaningful reductions in cortisol and anxiety scores at standardised doses of 250–600 mg/day for 6–12 weeks.

3 studies →

Lion's Mane

Hericium erinaceus

Lion's Mane (Hericium erinaceus) is most associated with nerve growth factor (NGF) signalling and mild cognitive benefit. Human evidence is still smaller than the brand category implies, but a 2025 Frontiers in Nutrition systematic review consolidates the dataset.

2 studies →

Magnesium Glycinate

Magnesium glycinate (bisglycinate) is the form best tolerated for sleep and stress because the glycine moiety is itself a sleep-supportive amino acid. Trial evidence supports modest improvements in sleep quality and onset, especially in adults with insufficient intake or insomnia.

2 studies →

Berberine

Berberine is one of the few botanical compounds with metabolic effects approaching those of pharmacological agents in trial settings — particularly on fasting glucose, HbA1c and lipid profile. Multiple meta-analyses converge on a real glucose-lowering effect.

3 studies →

Reishi

Ganoderma lucidum

Reishi (Ganoderma lucidum) is best characterised for its β-glucan polysaccharides and triterpenes, with a long traditional use for fatigue, sleep and immune balance. Modern reviews summarise an extensive mechanistic literature with a smaller but growing human dataset.

2 studies →

Turmeric

Curcuma longa

The active fraction of turmeric (curcuminoids) is one of the best-studied natural anti-inflammatory compounds. Multiple meta-analyses now show curcumin extracts produce clinically meaningful pain and function improvements in osteoarthritis comparable to NSAIDs in some trials.

2 studies →

Creatine

Creatine monohydrate is the single most-studied sports-nutrition supplement in existence, with hundreds of trials and the unusual position of being formally endorsed by the International Society of Sports Nutrition. Effects on strength, power and lean mass are robust and replicated.

2 studies →

CoQ10

CoQ10 (ubiquinone / ubiquinol) is a mitochondrial cofactor with the strongest clinical signal in heart-failure and statin-associated muscle symptoms. Cardiology reviews now consistently support adjunctive use.

2 studies →

Matcha

Camellia sinensis

Matcha's cognitive reputation is largely the L-theanine + caffeine combination, the single best-studied 'calm-alert' nootropic pairing. A 2014 Oxford-published meta-analysis remains the canonical reference, with newer reviews extending the data into matcha specifically.

3 studies →

Beetroot

Beta vulgaris

Beetroot's active is dietary nitrate, converted in the body to nitric oxide. The blood-pressure and exercise-performance signals are among the most reproducible in the entire functional-food literature.

2 studies →

Vitamin C

Vitamin C is one of the few supplements with a Cochrane-level review on its most-claimed use. The honest reading is: it does not prevent the common cold in the general population, but it modestly shortens duration and is more useful under physical stress.

2 studies →

Apple Cider Vinegar

ACV's clearest data is on post-meal glucose response and lipid profile — modest but reproducible effects. Weight-loss claims are smaller and noisier than the marketing implies.

2 studies →

Ginseng

Panax ginseng

Panax ginseng is one of the oldest documented adaptogens with a relatively strong fatigue-reduction signal in modern meta-analyses. Cognitive effects are smaller and more dependent on extract type.

2 studies →

Hyaluronic Acid

Oral hyaluronic acid has emerged from a curiosity to a moderately well-evidenced ingredient for skin hydration, elasticity and wrinkle depth — multiple recent randomised trials now show measurable improvement against placebo.

3 studies →

Retinol

Retinoids are the single most-evidenced topical anti-ageing ingredient class in dermatology. Prescription tretinoin has the deepest data; over-the-counter retinol shares the same mechanism with a lower potency, lower irritation profile.

2 studies →

Holy Basil

Ocimum sanctum

Tulsi (Ocimum sanctum) is the second-best-evidenced adaptogen we use after ashwagandha. The 2017 Jamshidi & Cohen systematic review is the canonical English-language summary — covering stress, metabolism, cognition and immunity.

2 studies →

Maca

Lepidium meyenii

Maca's most replicated finding is on subjective sexual function — particularly libido — independent of testosterone. Fertility and mood data are smaller and more variable.

2 studies →

Moringa

Moringa oleifera

Moringa oleifera leaf is exceptionally nutrient-dense and the meta-analytic data on glucose and lipid profile is increasingly favourable. It functions partly as a food and partly as a botanical extract.

2 studies →

L-Glutamine

L-glutamine is the primary fuel for enterocytes (gut-lining cells). The most rigorous human trial — Zhou et al. in Gut — showed clinically meaningful improvement in post-infectious IBS-D specifically.

2 studies →

NAD+

NAD+ precursors (NMN, NR) are the most-studied longevity supplements of the past decade. Multiple human RCTs now confirm they raise blood NAD+ — the question of clinical benefit beyond that biomarker is active research.

2 studies →

Chaga

Inonotus obliquus

Chaga (Inonotus obliquus) is exceptionally rich in melanin polymers, β-glucans and triterpenes. Mechanistic and pre-clinical data are extensive; controlled human-trial data is still developing.

2 studies →